European Journal of Pharmacology. PDF. FDA. July 19, 2000. Hyperglycemia and diabetes mellitus, in some cases extreme and associated with ketoacidosis or hyperosmolar coma or death, have been reported in patients treated with atypical antipsychotics. There have been few reports of hyperglycemia or diabetes in patients treated with Ziprasidone hydrochloride. Although fewer patients have been treated with Ziprasidone hydrochloride, it is not known if this more limited experience is the sole reason for the paucity of such reports. Assessment of the relationship between atypical antipsychotic use and glucose abnormalities is complicated by the possibility of an increased background risk of diabetes mellitus in patients with schizophrenia and the increasing incidence of diabetes mellitus in the general population. Given these confounders, the relationship between atypical antipsychotic use and hyperglycemia-related adverse reactions is not completely understood. Precise risk estimates for hyperglycemia-related adverse reactions in patients treated with atypical antipsychotics are not available.
Pooled data from short-term, placebo-controlled studies in schizophrenia are presented in Tables 1 to 2. Note that for the flexible dose studies in schizophrenia each subject is categorized as having received either low 20 to 40 mg BID or high 60 to 80 mg BID dose based on the subject's modal daily dose. No additional benefit was demonstrated for doses above 20 mg twice daily. Patients should be periodically reassessed to determine the need for maintenance treatment. Ziprasidone has not been systematically studied, in animals or humans, for its potential for abuse, tolerance, or physical dependence.
Ziprasidone may cause a condition that affects the heart rhythm QT prolongation. This list is not complete and there may be other drugs that should not be taken at the same time as ziprasidone. Tell your doctor about all medicines you use. Miceli JJ, Anziano RJ, Robarge L, Hansen RA, Laurent A 2000. In vivo studies have revealed no effect of Ziprasidone on the pharmacokinetics of estrogen or progesterone components. Dizziness caused by a drop in your blood pressure may occur with Ziprasidone hydrochloride, especially when you first start taking this medication or when the dose is increased. If this happens, be careful not to stand up too quickly, and talk to your doctor about the problem.
If you have any health problems, consult your doctor or pharmacist before using this product. If signs and symptoms of tardive dyskinesia appear in a patient on Ziprasidone, drug discontinuation should be considered. However, some patients may require treatment with Ziprasidone despite the presence of the syndrome. Oro Valley, AZ 85755. November 17, 2015. The risk of developing tardive dyskinesia and the likelihood that it will become irreversible are believed to increase as the duration of treatment and the total cumulative dose of antipsychotic drugs administered to the patient increase. However, the syndrome can develop, although much less commonly, after relatively brief treatment periods at low doses.
If prescribed by your doctor, use this medication for your current condition only. Do not use it later for other unless told to do so by your doctor. A different medication may be necessary in those cases. Miceli JJ, Smith M, Robarge L, Morse T, Laurent A 2000. QTc interval, including 1 bradycardia; 2 hypokalemia or hypomagnesemia; 3 concomitant use of other drugs that prolong the QTc interval; and 4 presence of congenital prolongation of the QT interval. Retrieved June 4, 2015. Your spouse or partner is cheating on you. Geodon ziprasidone hydrochloride US prescribing information. Pfizer Inc. QTc prolongations may also increase risk, or increase it in susceptible individuals. Recently, the FDA required the manufacturers of some atypical antipsychotics to include a warning about the risk of and with atypical antipsychotics. It is not known whether Ziprasidone or its metabolites are excreted in human milk. It is recommended that women receiving Ziprasidone should not breastfeed. Seeger TF, Seymour PA, Schmidt AW, et al. October 1995. This drug may rarely make your blood sugar level rise, which can cause or worsen diabetes. Tell your doctor right away if you develop symptoms of high blood sugar, such as increased thirst and urination. If you already have diabetes, be sure to check your blood sugars regularly. Your doctor may need to adjust your diabetes medication, exercise program, or diet. Ziprasidone and other drugs that prolong the QT interval have not been performed. An additive effect of Ziprasidone and other drugs that prolong the QT interval cannot be excluded.
It is unknown if this drug passes into breast milk. Because of the possible risk to the infant, breast-feeding while using this drug is not recommended. Consult your doctor before breast-feeding. Ziprasidone 20, 60, and 100 mg twice daily with placebo, all three dose groups were superior to placebo on the PANSS total score, the BPRS total score, the BPRS psychosis cluster, and the CGI severity score. Only the 100 mg twice daily dose group was superior to placebo on the PANSS negative subscale score. There was no clear evidence for a dose-response relationship within the 20 mg twice daily to 100 mg twice daily dose range. Also, tell your doctor if you low levels of potassium or magnesium in your blood, if you use or have ever used street drugs or have overused prescription medications, or have trouble swallowing. Also tell your doctor if you have severe diarrhea or vomiting or you think you may be dehydrated. As with other antipsychotics, long-term use of ziprasidone may lead to a potentially irreversible condition called tardive dyskinesia involuntary movements of the jaw, lips, and tongue. British Journal of Clinical Pharmacology. Positive, encouraging support from family and friends really helps, too. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. Drowsiness, dizziness, lightheadedness, weakness, nausea, vomiting, runny nose, and cough may occur. If any of these effects persist or worsen, tell your doctor promptly. If any of these effects persist or worsen, tell your doctor promptly. Sacher J, Mossaheb N, Spindelegger C, et al. June 2008. quibron
Ziprasidone was tested in the Ames bacterial mutation assay, the in vitro mammalian cell gene mutation mouse lymphoma assay, the in vitro chromosomal aberration assay in human lymphocytes, and the in vivo chromosomal aberration assay in mouse bone marrow. There was a reproducible mutagenic response in the Ames assay in one strain of S. typhimurium in the absence of metabolic activation. Positive results were obtained in both the in vitro mammalian cell gene mutation assay and the in vitro chromosomal aberration assay in human lymphocytes. Side Effects List Imipramine Hcl side effects by likelihood and severity. One case of priapism was reported in the premarketing database. While the relationship of the reaction to Ziprasidone use has not been established, other drugs with alpha-adrenergic blocking effects have been reported to induce priapism, and it is possible that Ziprasidone may share this capacity. Severe priapism may require surgical intervention. Ziprasidone hydrochloride is an effective drug to treat the symptoms of schizophrenia. However, one potential side effect is that it may change the way the electrical current in your heart works more than some other drugs. Tatsumi M, Jansen K, Blakely RD, Richelson E March 1999. "Pharmacological profile of neuroleptics at human monoamine transporters". European Journal of Pharmacology. generic enalapril 10 mg enalapril
Who Should Take Ziprasidone Hydrochloride Capsules? NMS can occur with all antipsychotic medications including Ziprasidone hydrochloride. Signs of NMS include very high fever, rigid muscles, shaking, confusion, sweating, or increased heart rate and blood pressure. NMS is a rare but serious side effect that could be fatal. Therefore, tell your doctor if you experience any of these signs. About FAERS: The FDA Adverse Event Reporting System FAERS is used by FDA for activities such as looking for new safety concerns that might be related to a marketed product, evaluating a manufacturer's compliance to reporting regulations and responding to outside requests for information. Reporting of adverse events is a voluntary process, and not every report is sent to FDA and entered into FAERS. Retrieved December 12, 2014. Take this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day. It is important to continue taking this medication even if you feel well. Do not stop taking this medication without consulting your doctor. If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. There was no evidence to suggest that these developmental effects were secondary to maternal toxicity. Let your doctor know right away if you notice an irregular heartbeat or have any dizziness or fainting episodes. Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first. What Is Ziprasidone Hydrochloride? Do not start, stop, or change the dosage of any medicines without your doctor's approval. In case of an overdose, call your doctor or poison control center right away or go to the nearest emergency room. Keep Ziprasidone hydrochloride capsules and all medicines out of the reach of children. Drug Reaction with Eosinophilia and Systemic Symptoms DRESS has been reported with Ziprasidone exposure. DRESS consists of a combination of three or more of the following: cutaneous reaction such as rash or exfoliative dermatitis eosinophilia, fever, lymphadenopathy and one or more systemic complications such as hepatitis, nephritis, pneumonitis, myocarditis, and pericarditis. DRESS is sometimes fatal. Discontinue Ziprasidone if DRESS is suspected.
QTdrugs List, AZCERT, Inc. In the rat study, there was no evidence of an increased incidence of tumors compared to controls. In male mice, there was no increase in incidence of tumors relative to controls. Ziprasidone hydrochloride monohydrate is a white to slightly pink powder. Ziprasidone may cause other side effects. Call your doctor if you have any unusual problems while taking this medication. NMS has been reported with other anti-psychotic drugs. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. Observational studies suggest that, similar to atypical antipsychotic drugs, treatment with conventional antipsychotic drugs may increase mortality. The extent to which the findings of increased mortality in observational studies may be attributed to the antipsychotic drug as opposed to some characteristics of the patients is not clear. Ziprasidone has not been evaluated or used to any appreciable extent in patients with a recent history of myocardial infarction or unstable heart disease. Patients with these diagnoses were excluded from premarketing clinical studies. Rarely, males may have a painful or prolonged erection lasting 4 or more hours. If this occurs, stop using this drug and get medical help right away, or permanent problems could occur. The absolute bioavailability of a 20 mg dose under fed conditions is approximately 60%. There have been reports of agitation, hypertonia, hypotonia, tremor, somnolence, respiratory distress and feeding disorder in these neonates. These complications have varied in severity; while in some cases symptoms have been self-limited, in other cases neonates have required intensive care unit support and prolonged hospitalization. can you ivermectin at walmart ivermectin
This information is generalized and not intended as specific medical advice. Serious. These medicines may interact and cause very harmful effects. Tell your doctor if you plan to do vigorous exercise or be exposed to extreme heat. Remember to keep taking your capsules, even when you feel better. Neuroleptic Malignant Syndrome NMS has been reported in association with administration of antipsychotic drugs. Clinical manifestations of NMS are hyperpyrexia, muscle rigidity, altered mental status, and evidence of autonomic instability irregular pulse or blood pressure, tachycardia, diaphoresis, and cardiac dysrhythmia. Additional signs may include elevated creatinine phosphokinase, myoglobinuria rhabdomyolysis and acute renal failure. Discuss the risks and benefits of treatment with your doctor. The government is spying on you. Retrieved October 16, 2016. People with paranoid delusions are unreasonably suspicious of others. This can make it hard for them to hold a job, run errands, have friendships, and even go to the doctor. Baldassano CF, Ballas C, Datto SM, et al. February 2003. Although not reported with Ziprasidone in premarketing trials, disruption of the body's ability to reduce core body temperature has been attributed to antipsychotic agents. tinidazole purchase now australia
HOW TO USE: Read the Patient Information Leaflet if available from your pharmacist before you start taking ziprasidone and each time you get a refill. If you have any questions, ask your doctor or pharmacist. It is essential to periodically monitor serum electrolytes in patients for whom diuretic therapy is introduced during Ziprasidone treatment. Persistently prolonged QTc intervals may also increase the risk of further prolongation and arrhythmia, but it is not clear that routine screening ECG measures are effective in detecting such patients. Ziprasidone may induce orthostatic hypotension associated with dizziness, tachycardia, and, in some patients, syncope, especially during the initial dose-titration period, probably reflecting its α 1-adrenergic antagonist properties. The systemic of ziprasidone is 100% when administered intramuscularly and 60% when administered orally without food. Ziprasidone, and all patients experiencing these reactions were reported to recover completely. Upon appearance of rash for which an alternative etiology cannot be identified, Ziprasidone should be discontinued. There is no known treatment for established cases of tardive dyskinesia, although the syndrome may remit, partially or completely, if antipsychotic treatment is withdrawn. Antipsychotic treatment itself, however, may suppress or partially suppress the signs and symptoms of the syndrome, and thereby may possibly mask the underlying process. The effect that symptomatic suppression has upon the long-term course of the syndrome is unknown. GJ, Roden DM, Zareba W. Prevention of torsade de pointes in hospital settings: a scientific statement from the American Heart Association and the American College of Cardiology Foundation. Monti JM March 2010. "Serotonin 5-HT2A receptor antagonists in the treatment of insomnia: present status and future prospects.
The management of NMS should include: 1 immediate discontinuation of antipsychotic drugs and other drugs not essential to concurrent therapy; 2 intensive symptomatic treatment and medical monitoring; and 3 treatment of any concomitant serious medical problems for which specific treatments are available. There is no general agreement about specific pharmacological treatment regimens for NMS. Sandson NB, Armstrong SC, Cozza KL 2005. "An overview of psychotropic drug-drug interactions". Psychosomatics. If you are planning pregnancy, become pregnant, or think you may be pregnant, immediately discuss with your doctor the benefits and risks of using this medication during pregnancy. Daniel DG, Zimbroff DL, Potkin SG, Reeves KR, Harrigan EP, Lakshminarayanan M May 1999. While there is no body of evidence available to answer the question of how long a patient treated with Ziprasidone should remain on it, a maintenance study in patients who had been symptomatically stable and then randomized to continue Ziprasidone or switch to placebo demonstrated a delay in time to relapse for patients receiving Ziprasidone hydrochloride. If you have schizophrenia, you are more likely to develop diabetes than people who do not have schizophrenia, and taking ziprasidone or similar medications may increase this risk. Tell your doctor immediately if you have any of the following symptoms while you are taking ziprasidone: extreme thirst, frequent urination, extreme hunger, blurred vision, or weakness. It is very important to call your doctor as soon as you have any of these symptoms, because high blood sugar that is not treated can cause a serious condition called ketoacidosis. Ketoacidosis may become life-threatening if it is not treated at an early stage. Symptoms of ketoacidosis include dry mouth, nausea and vomiting, shortness of breath, breath that smells fruity, and decreased consciousness. Using the two medicines together may cause an irregular heartbeat, which may be life-threatening. Fallucco, Elise M. 2009. "Ziprasidone". There are some medications that may be unsafe to use when taking Ziprasidone hydrochloride, and there are some medicines that can affect how well Ziprasidone hydrochloride works. Patients with an established diagnosis of diabetes mellitus who are started on atypical antipsychotics should be monitored regularly for worsening of glucose control. promethazine online quebec
The risk is about 1 in 200 patients. Alzheimer's dementia. Conditions that lower the seizure threshold may be more prevalent in a population of 65 years or older. Ziprasidone 10% compared to placebo 4%. Weight gain is also less of a concern with Ziprasidone compared to other atypical antipsychotics. Swallow the capsules whole. Table 6 enumerates the incidence, rounded to the nearest percent, of treatment-emergent adverse reactions that occurred during acute therapy up to 6 weeks in predominantly patients with schizophrenia, including only those reactions that occurred in 2% or more of patients treated with Ziprasidone and for which the incidence in patients treated with Ziprasidone was greater than the incidence in placebo-treated patients. This medication may rarely cause a very serious condition called neuroleptic malignant syndrome NMS. sorf.info benicar
United Kingdom: Royal Pharmaceutical Society of Great Britain. Class Ia and III anti-arrhythmics, mesoridazine, thioridazine, chlorpromazine, droperidol, pimozide, sparfloxacin, gatifloxacin, moxifloxacin, halofantrine, mefloquine, pentamidine, arsenic trioxide, levomethadyl acetate, dolasetron mesylate, probucol or tacrolimus. The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongation. Before using ziprasidone, tell your doctor or pharmacist of all the drugs you take and if you have any of the following conditions: certain heart problems heart failure, recent heart attack, slow heartbeat, QT prolongation in the EKG family history of certain heart problems QT prolongation in the EKG, sudden cardiac death. This drug has also been used in combination with other medication to treat depression. Anything that can increase the chance of a heart rhythm abnormality should be avoided. Patients with neutropenia should be carefully monitored for fever or other symptoms or signs of infection and treated promptly if such symptoms or signs occur. PDF. FDA Center For Drug Evaluation And Research. May 26, 1998. When ziprasidone is taken with moxifloxacin or sparfloxacin, the effects on your heart may be increased. The possibility of a suicide attempt is inherent in psychotic illness and close supervision of high-risk patients should accompany drug therapy. Prescriptions for Ziprasidone should be written for the smallest quantity of capsules consistent with good patient management in order to reduce the risk of overdose. If a patient requires antipsychotic drug treatment after recovery from NMS, the potential reintroduction of drug therapy should be carefully considered. The patient should be carefully monitored, since recurrences of NMS have been reported. Patients should be instructed to report the onset of any conditions that put them at risk for significant electrolyte disturbances, hypokalemia in particular, including but not limited to the initiation of diuretic therapy or prolonged diarrhea. Take this medication by mouth with food as directed by your doctor, usually twice daily. Swallow the capsules whole.
Patients being considered for Ziprasidone treatment that are at risk of significant electrolyte disturbances should have baseline serum potassium and magnesium measurements. Low serum potassium and magnesium should be replaced before proceeding with treatment. Patients who are started on diuretics during Ziprasidone therapy need periodic monitoring of serum potassium and magnesium. If you notice any of these symptoms in your newborn especially during their first month, tell the doctor right away. This medication can cause birth defects, according to animal studies, although this side effect has not been confirmed in humans. Ziprasidone. Of these 5700, over 4800 were patients who participated in multiple-dose effectiveness trials, and their experience corresponded to approximately 1831 patient-years. These patients include 1 4331 patients who participated in multiple-dose trials, predominantly in schizophrenia, representing approximately 1698 patient-years of exposure. The conditions and duration of treatment with Ziprasidone included open-label and double-blind studies, inpatient and outpatient studies, and short-term and longer-term exposure. QT prolongation and arrhythmia. Hypokalemia may result from diuretic therapy, diarrhea, and other causes. Tell your doctor or pharmacist if you are taking other products that cause drowsiness including alcohol, antihistamines such as cetirizine, diphenhydramine drugs for sleep or anxiety such as alprazolam, diazepam, zolpidem muscle relaxants, and narcotic pain relievers such as codeine. You are currently taking medications that should not be taken in combination with Ziprasidone, for example, dofetilide, sotalol, quinidine, other Class Ia and III anti-arrhythmics, mesoridazine, thioridazine, chlorpromazine, droperidol, pimozide, sparfloxacin, gatifloxacin, moxifloxacin, halofantrine, mefloquine, pentamidine, arsenic trioxide, levomethadyl acetate, dolasetron mesylate, probucol or tacrolimus. Some side effects can be serious. order generic propranolol store europe
All reported reactions are included except those already listed in Table 6 or elsewhere in labeling, those reaction terms that were so general as to be uninformative, reactions reported only once and that did not have a substantial probability of being acutely life-threatening, reactions that are part of the illness being treated or are otherwise common as background reactions, and reactions considered unlikely to be drug-related. Undesirable alterations in lipids have been observed in patients treated with atypical antipsychotics. Pooled data from short-term, placebo-controlled studies in schizophrenia are presented in Tables 3-4. It affects how you think and behave. This can show up in different ways and at different times, even in the same person. The illness usually starts in late adolescence or young adulthood. Adverse reactions related to high blood sugar hyperglycemia sometimes serious, have been reported in patients treated with atypical antipsychotics. There have been few reports of hyperglycemia or diabetes in patients treated with Ziprasidone hydrochloride, and it is not known if Ziprasidone hydrochloride is associated with these reactions. Patients treated with an atypical antipsychotic should be monitored for symptoms of hyperglycemia. Warning: The facts and figures contained in these reports are accurate to the best of our capability; however, our metrics are only meant to augment your medical knowledge, and should never be used as the sole basis for selecting a new medication. As with any medical decision, be sure to work with your doctor to ensure the best choices are made for your condition. Only your doctor can decide if Ziprasidone hydrochloride capsules are right for you. CBC monitored frequently during the first few months of therapy and should discontinue Ziprasidone hydrochloride at the first sign of decline in WBC in the absence of other causative factors. You might have to take different kinds of drugs for other symptoms, too. Once your delusions are under control, counseling can help you get along with others, hold a job, go to school, take care of yourself, and have friends. Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. Class Effect: Symptoms of dystonia, prolonged abnormal contractions of muscle groups, may occur in susceptible individuals during the first few days of treatment. Talk to your doctor about using ziprasidone safely. Ziprasidone. There were confounding factors that may have contributed to the occurrence of seizures in many of these cases. lopid
ziprasidone money order now uk, is generic ziprasidone as good as brand, order cheapest ziprasidone payment, ziprasidone boston, generic for ziprasidone 500mg, generic ziprasidone online australia, shop ziprasidone buller, pharmacy ziprasidone cost, where to buy ziprasidone in australia, cheap ziprasidone mastercard, order ziprasidone online visa uk, buy ziprasidone shop australia, ziprasidone in uk, is ziprasidone in us, buy ziprasidone online in canada, buy ziprasidone online cheap canada, buy ziprasidone capsules, buy ziprasidone otc online, order cheap ziprasidone mastercard usa, reload ziprasidone, ziprasidone es generic name, where to buy liquid ziprasidone, cheapest ziprasidone buy mastercard australia, ziprasidone buy mastercard uk, buy cheap ziprasidone payment, order ziprasidone guidelines, ziprasidone doctors canada, order now ziprasidone shop usa, purchase now ziprasidone visa australia, buy now ziprasidone uk, ziprasidone brand online uk, buy ziprasidone from trusted pharmacy, price ziprasidone work, purchase ziprasidone high, ziprasidone pills buy online shop, what tesco store sells ziprasidone, mail order cheapest ziprasidone payment, order ziprasidone online mastercard, order ziprasidone online reviews, money order now ziprasidone pharmacy, prescription ziprasidone strength, price ziprasidone 40mg tab, buy ziprasidone mexico, ziprasidone 150 mg, ziprasidone 100mg price walmart, cheap ziprasidone yahoo, ziprasidone tablets order online mastercard, buy ziprasidone boots online, generic ziprasidone information, buy ziprasidone no prescription, ziprasidone thailand, ziprasidone where to order usa, ziprasidone price ebay, buy ziprasidone in singapore, buying ziprasidone without insurance, money order now ziprasidone payment, purchase ziprasidone online reviews, buy now ziprasidone shop otc, canada ziprasidone side, buy now cheapest ziprasidone otc, ziprasidone facebook canada, buy cheap ziprasidone shop europe, store ziprasidone indication, buy ziprasidone from usa, buy ziprasidone online payment canada, ziprasidone online mastercard money order, buy ziprasidone boots uk, average cost ziprasidone, ziprasidone purchase now australia, ziprasidone online quebec, discount ziprasidone prices, order generic ziprasidone store europe, can you ziprasidone at walmart, generic ziprasidone 10 mg
Several instruments were used for assessing psychiatric signs and symptoms in these studies. The Brief Psychiatric Rating Scale BPRS and the Positive and Negative Syndrome Scale PANSS are both multi-item inventories of general psychopathology usually used to evaluate the effects of drug treatment in schizophrenia. The BPRS psychosis cluster conceptual disorganization, hallucinatory behavior, suspiciousness, and unusual thought content is considered a particularly useful subset for assessing actively psychotic schizophrenic patients. A second widely used assessment, the Clinical Global Impression CGI reflects the impression of a skilled observer, fully familiar with the manifestations of schizophrenia, about the overall clinical state of the patient. In addition, the Scale for Assessing Negative Symptoms SANS was employed for assessing negative symptoms in one trial. discount celebrex prices
Agranulocytosis including fatal cases has also been reported. Hagop S. Akiskal; Mauricio Tohen June 24, 2011. Ziprasidone belongs to a class of drugs called atypical antipsychotics. It works by helping to restore the balance of certain natural substances in the brain. Your doctor may want you to get additional laboratory tests to see if Ziprasidone hydrochloride capsule is an appropriate treatment for you.
If you recognize that you're having trouble, you can be admitted voluntarily. But if you think you don't need help when you really do, the law may allow a doctor or other mental health professional to admit you involuntarily. Leucht, S; et al. 2013. Refer to the storage information printed on the package. Protect from light and moisture. not store in the bathroom.
Keep all drug products away from children and pets. It is best to take Ziprasidone hydrochloride capsules at the same time each day. Citrome, L; Yang, R; Glue, P; Karayal, ON June 2009. "Effect of ziprasidone dose on all-cause discontinuation rates in acute schizophrenia and schizoaffective disorder: a post-hoc analysis of 4 fixed-dose randomized clinical trials. People with schizophrenia who get counseling are also more likely to stick with their medications. Severe. These medicines may interact and cause very harmful effects and are usually not taken together.